Systematic inflammation is the result of almost every major disease, right from joint pain to gut disorders, autoimmune flares and neurodegenerative issues. It has become so common that the majority of people you see and think have gotten fat are actually suffering from systemic inflammation, which makes their condition far worse. For a long time, research and studies have been done to find a solution to deal with this problem, and we might have gotten lucky.
Anti-inflammatory peptides have been developed by researchers, and they are changing the traditional way of medication to treat inflammation. But before you start using it, you must understand its properties and how it came into existence. Many of these peptides can be sourced from CellPeptides if you are living in Europe or USA with fast shipping and no customs.
A Brief on Anti-inflammatory Peptides
Anti-inflammatory peptides are synthetic peptides that mimic the natural component like α-MSH. This peptide present in our body plays a great role in our immune regulation systems, but often gets overwhelmed or reduced by the excessive inflammation caused by diseases. To tackle its production and address its gradual decrease, scientists developed anti-inflammation peptides, and there is not just one, but a few that are being researched for calming the systemic inflammation.
Let’s have a look at the best 7 peptides for systemic inflammation:
BPC-157
BPC-157 stands for Body Protection Compound-157 and is a synthetic peptide that is derived from a protein found in gastric juice. It is still being researched for the possible benefits it offers for reducing and calming systemic inflammation. However, some past research and studies have already shown that BPC-157 may possess anti-inflammatory and tissue healing properties by controlling inflammation pathways, supporting regeneration of muscles, ligaments, nerves, and gut lining, and protecting blood vessels.
It might have the ability to influence nitric oxide, which can further help with improving the blood flow and support the healing of inflamed tissues. When tested on animals, it showed to reduce the inflammatory markers and protect form inflammatory damages, triggering speed recovery.
KPV
A small anti-inflammatory peptide, KPV, is made of three amino acids (Lysine-Proline-Valine) derived from Alpha-MSH, which is a larger hormone. Many studies done on this peptide have shown that it has the ability of reducing systemic inflammation by calming overactive immune responses. The same researches show that by preventing pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6, KPV interferes with NF-κB signalling, a major pathway responsible for driving chronic inflammation in the body.
KPV dampens these signals and protects the tissues from prevailing inflammatory issues, and offers healing in areas like skin, gut, and others. It has shown great potential in maintaining the integrity of the epithelial barrier like the gut lining, which often worsens the systemic inflammation.
LL-37
LL-37 is a naturally formed human antimicrobial peptide that comes from the cathelicidin family and has great potential in treating systematic inflammation caused by immune-modulating and antimicrobial properties. It directly kills the bacteria, viruses and fungi by destroying their membrane, which is responsible for worsening the inflammation conditions. As LL-36 functions like an immunomodulator, it influences major inflammatory pathways and attracts immune cells to strike a balance at the spots of the injury and infection.
In some cases, LL-37 resolves inflammation by promoting tissue repair, supporting wound healing, tissue repair, and maintaining the integrity of physical barriers like skin and mucosal lining, which, when compromised, can further elevate the inflammation condition.
TB-500
A synthetic peptide, TB-500, is a fragment of thymosin beta-4 and a naturally occurring protein found in tissue repair, regeneration, and migration, but has always been discussed in the context of systematic inflammation. It contains anti-inflammatory and healing properties, which have been shown in experiments and research done on animals. TB-500 promotes actin polymerization, supports the migration of repair cells, and helps blood vessel growth on the sites of injury, and together they help tissues recover from the inflammatory damage.
Studies also show that TB-500 also reduces the levels of certain inflammatory markers and protects the vital organs from developing inflammation caused by injuries. It helps with microcirculation and encourages faster healing of tendons, muscles, and soft tissues and indirectly lowers systematic inflammatory caused by chronic tissue damage.
Larazotide
An oral peptide, Larazotide, targets the core of the gut barrier and plays a crucial role in treating systematic inflammation caused mainly by the leaky gut. It modulates the tight junction, which is a microscopic gatekeeper between cells that sits on the lining of the small intestine. When these junctions loosen, large food particles, bacterial components, and toxins pass into the bloodstream, further contributing to systemic inflammation.
Larazotide tightens and stabilises these junctions, limits the flow of inflammatory triggers, and reduces intestinal permeability. In the latest studies done for celiac disease, it showed that Larazotide reduces inflammatory markers by reducing gluten-induced permeability.
GHK-Cu
A naturally occurring copper-binding peptide, GHK-Cu, is found in human tissues, saliva, and plasma. It’s known in the research world for its antioxidant, regenerative, and anti-inflammatory properties. When talking in the context of systematic inflammation, GHK-Cu works great and many studies have backed its capability for treating the same. It downregulates pro-inflammatory genes and cytokines and upregulates genes connected with antioxidant defence, tissue repair, and anti-inflammatory signalling.
GHK-Cu has also shown results to improve blood vessel growth, support the functions of fibroblasts and stem cells, and improve microcirculation, all of which contribute to better recovery from injuries and chronic inflammatory damage.
Semaglutide
Originally developed for type 2 diabetes and obesity, Semaglutide is a GLP-1 receptor agonist and has great effect on systematic inflammation because of the property of improving metabolic health. It mimics the incretin hormone GLP-1 and enhances insulin secretion when the blood sugar is high, helps with weight loss, and improves blood glucose control. Gut fat and chronic high blood sugar contribute to low-grade systemic inflammation.
Studies done on Semaglutide show that it can reduce inflammatory markers, improve blood vessel functions, and lower oxidative stress.
Systematic inflammation is a prevailing issue and follows as an aftermath post suffering many major diseases. While many medicines and other ways have been invented, nothing comes close to peptides because of their effective results, and they are still being researched for the same purpose to further prove their maximum efficiency. These 7 peptides have shown the most effective results by far out of all researched peptides.
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